HORDB

ID: hor004026
Uniprot ID: Q6DQW2(100-111)
Protein name: Pyrokinin
Gene name: CAPA
Organism: Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Family: Pyrokinin family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Manduca (genus), Sphingini (tribe), Sphinginae (subfamily), Sphingidae (family), Bombycoidea (superfamily), Obtectomera, Ditrysia, Heteroneura (parvorder), Neolepidoptera (infraorder), Glossata (suborder), Lepidoptera (order), Amphiesmenoptera (superorder), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: TEGPGMWFGPRL
Length: 12(100-111)
Propeptide: MQSAVRLVVCLFLLSSVLGGSYQSGPKLRRDGVLNLYPFPRVGRASHHTWQIPINDLYLEYDPVDKRQLYAFPRVGRSELSLLRPEQHLDALQPVPARRTEGPGMWFGPRLGRSFKSDEDEITIQNNNLERSEPELMERKKRNAHLN
Signal peptide: MQSAVRLVVCLFLLSSVLG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004026_AF2.pdb

hor004026_ESM.pdb

Mass:	154393	Formula:	C62H90N16O16S
Absent amino acids:	ACDHIKNQSVY	Common amino acids:	G
pI:	6.41	Basic residues:	1
Polar residues:	4	Hydrophobic residues:	3
Hydrophobicity:	-45.83	Boman Index:	-890
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	32.5
Instability Index:	1893.33	Extinction Coefficient cystines:	5500
Absorbance 280nm:	500

PubMed ID: 19350635
Title: Identification of Novel Neuropeptides in the Ventral Nerve Cord Ganglia and Their Targets in an Annelid Worm, Eisenia Fetida